Investigation on the mechanism of amyloid beta peptides oligomerization and the process for its inhibition

• Main Author: Zhao, Li Na
• Other Authors: Mu Yuguang
• Format: Theses and Dissertations
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Biophysics
• Online Access: https://hdl.handle.net/10356/55043
• Institution: Nanyang Technological University

Amyloid beta (Abeta) plaque, which is a characteristic hallmark of Alzheimer’s disease (AD), results from the deposition of Abeta peptides. Amyloid beta peptides are prone to self assembly into high-order oligomers, which is the major pathological pathway of AD. It is generally believed that the Abe...