Activation of alkynes with [Cp*MCl2]2 (M=Rh or Ir) towards hydroamination reactions
Abstract Activation of alkynes for hydroamination reactions have been studied with the iridium and rhodium dimeric complexes [Cp*MCl2]2 (M=Rh or Ir). The reaction of [Cp*IrCl2]2, 1a with terminal alkynes and anilines afforded a variety of iridium amino-carbenes, whereas the rhodium analogue 1b gave...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2014
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| Online Access: | https://hdl.handle.net/10356/58906 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Abstract
Activation of alkynes for hydroamination reactions have been studied with the iridium and rhodium dimeric complexes [Cp*MCl2]2 (M=Rh or Ir). The reaction of [Cp*IrCl2]2, 1a with terminal alkynes and anilines afforded a variety of iridium amino-carbenes, whereas the rhodium analogue 1b gave a range of metallacycles. In the presence of additives, 1b was found to catalyse the hydroamination of alkynes with anilines to afford ketimines or 1,2-dihydroquinolines. Similarly, 1a could catalyse the hydroamination of 2-alkynylanilines to yield 2,2’-biindoles or indoles. The pathways for these reactions have been studied using a combination of experimental and computational methods. |
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