Characterization of zebrafish IKK2 mutants generated by zinc finger nucleases

• Main Author: Ho, Foo Kiong
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2014
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/59585
• Institution: Nanyang Technological University

IκB kinase β (IKK2/IKKβ) is known as a master regulator of NF-κB signaling, which mediates stress, immune and inflammatory responses. Unfortunately, embryonic lethality in IKK2-deficient mice hinders studies of zygotic IKK2 function beyond embryonic stages. Although conditional knockout mice have be...