Modulators of the p53-MDM2 interaction : search for MDM2 interactors using structural guidance

• Main Author: Lin, Jianqing
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2014
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/60604
• Institution: Nanyang Technological University

The interaction between MDM2 and p53 is essential for several cellular events, including cell growth, DNA repair, cell cycle arrest and apoptosis. So far, p53 is the only known protein that binds to the hydrophobic pocket of MDM2. In this study, we tried to identify other proteins that also interact...