Studying the role of protein deamidation in neurodegenerative disease in proteome-wide scale

• Main Author: Ang, Yi Lin
• Other Authors: Sze Siu Kwan
• Format: Final Year Project
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/60613
• Institution: Nanyang Technological University

Deamidation had been associated with amyloid-β peptide and tau protein aggregation in Alzheimer’s disease. Our previous study detected dysregulation of membrane proteins in vascular dementia, and a review of the data revealed extensive deamidation of Na+/K+- ATPase. Taken together, deamidation might...