c-Abl, an accomplice in mutant p53 gain-of-function?

• Main Author: Liu, Di
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2014
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/60624
• Institution: Nanyang Technological University

Accumulating evidence indicates that mutant p53 (mutp53) has further effects on cancer cells apart from causing the loss of wild type p53 (wtp53) tumour suppressor functions. The pro-metastatic functions of mutant p53 (mutp53) result in a worse prognosis and are often lethal. Although mutp53 is well...