Multi-drug-loaded gastric-floating microcapsules
Recent advances in floating drug delivery systems (FDDS) have been developed to increase drug bioavailability and reduce patients’ dosing frequency and pill burden, by means of an effective sustained release. Nevertheless, with most hydrophobic drugs unable to achieve complete release within the gas...
Saved in:
Main Author: | |
---|---|
Other Authors: | |
Format: | Theses and Dissertations |
Language: | English |
Published: |
2014
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/61829 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
id |
sg-ntu-dr.10356-61829 |
---|---|
record_format |
dspace |
spelling |
sg-ntu-dr.10356-618292023-03-04T16:36:23Z Multi-drug-loaded gastric-floating microcapsules Tan, Melvin Jun Wei Loo Say Chye Joachim School of Materials Science & Engineering DRNTU::Engineering::Materials::Biomaterials Recent advances in floating drug delivery systems (FDDS) have been developed to increase drug bioavailability and reduce patients’ dosing frequency and pill burden, by means of an effective sustained release. Nevertheless, with most hydrophobic drugs unable to achieve complete release within the gastrointestinal (GI) residence period (10 hours for FDDS), an understanding of how to promote drug release in such systems is essential. This study explores modified gastro-retentive polymeric floating microcapsule fabricating processes that simultaneously release metformin hydrochloride, a hydrophilic drug, and fenofibrate, a hydrophobic drug, in a controlled manner, seeking to promote the release rate of the hydrophobic drug. A comparable study using a solvent evaporation method to create multi-drug gastric floating microcapsules achieved 86% metformin hydrochloride release and only 20% fenofibrate release within 10 hours. The first process developed in this study using a spray-coating technique could achieve 87% to 100% metformin hydrochloride release within 10 hours and 100% fenofibrate release between 1 to 10 hours by parameter variation. The second process created bi-layer gastric floating microspheres in a single-step process achieving 100% fenofibrate release within 10 hours. The study also explored a fabrication technique where spray-coated gastric floating microcapsules were capable of producing loading dose and maintenance dose. MASTER OF ENGINEERING (MSE) 2014-11-06T00:48:33Z 2014-11-06T00:48:33Z 2014 2014 Thesis Tan, M. J. W. (2014). Multi-drug-loaded gastric-floating microcapsules. Master’s thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/61829 10.32657/10356/61829 en 100 p. application/pdf |
institution |
Nanyang Technological University |
building |
NTU Library |
continent |
Asia |
country |
Singapore Singapore |
content_provider |
NTU Library |
collection |
DR-NTU |
language |
English |
topic |
DRNTU::Engineering::Materials::Biomaterials |
spellingShingle |
DRNTU::Engineering::Materials::Biomaterials Tan, Melvin Jun Wei Multi-drug-loaded gastric-floating microcapsules |
description |
Recent advances in floating drug delivery systems (FDDS) have been developed to increase drug bioavailability and reduce patients’ dosing frequency and pill burden, by means of an effective sustained release. Nevertheless, with most hydrophobic drugs unable to achieve complete release within the gastrointestinal (GI) residence period (10 hours for FDDS), an understanding of how to promote drug release in such systems is essential. This study explores modified gastro-retentive polymeric floating microcapsule fabricating processes that simultaneously release metformin hydrochloride, a hydrophilic drug, and fenofibrate, a hydrophobic drug, in a controlled manner, seeking to promote the release rate of the hydrophobic drug. A comparable study using a solvent evaporation method to create multi-drug gastric floating microcapsules achieved 86% metformin hydrochloride release and only 20% fenofibrate release within 10 hours. The first process developed in this study using a spray-coating technique could achieve 87% to 100% metformin hydrochloride release within 10 hours and 100% fenofibrate release between 1 to 10 hours by parameter variation. The second process created bi-layer gastric floating microspheres in a single-step process achieving 100% fenofibrate release within 10 hours. The study also explored a fabrication technique where spray-coated gastric floating microcapsules were capable of producing loading dose and maintenance dose. |
author2 |
Loo Say Chye Joachim |
author_facet |
Loo Say Chye Joachim Tan, Melvin Jun Wei |
format |
Theses and Dissertations |
author |
Tan, Melvin Jun Wei |
author_sort |
Tan, Melvin Jun Wei |
title |
Multi-drug-loaded gastric-floating microcapsules |
title_short |
Multi-drug-loaded gastric-floating microcapsules |
title_full |
Multi-drug-loaded gastric-floating microcapsules |
title_fullStr |
Multi-drug-loaded gastric-floating microcapsules |
title_full_unstemmed |
Multi-drug-loaded gastric-floating microcapsules |
title_sort |
multi-drug-loaded gastric-floating microcapsules |
publishDate |
2014 |
url |
https://hdl.handle.net/10356/61829 |
_version_ |
1759858163226509312 |