Design and examine oligonucleotide structures as inhibitors to topoisomerase IV

Topoisomerase IV is an enzyme that exclusively presents in prokaryotic cells and is mainly responsible for unwinding interlocked DNA strands at the final stage of prokaryotic replication. Since it is a prokaryotic enzyme, various types of quinolones were developed in the past as inhibitors of topo I...

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Bibliographic Details
Main Author: Guo, Juanjuan
Other Authors: Shao Fangwei
Format: Theses and Dissertations
Language:English
Published: 2014
Subjects:
Online Access:http://hdl.handle.net/10356/61861
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Institution: Nanyang Technological University
Language: English
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