Activation of aldehydes via oxidative n-heterocyclic carbene catalysis

My Ph.D research mainly focuses on developing new reactions and synthetic methods via oxidative N-Heterocyclic Carbene catalysis. This thesis contains four major parts: Chapter 1 gives a brief introduction to history and present development of NHC catalysis, and shows the challenges in NHC catalysis...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Mo, Junming
مؤلفون آخرون: Chi Yonggui
التنسيق: Theses and Dissertations
اللغة:English
منشور في: 2015
الموضوعات:
الوصول للمادة أونلاين:https://hdl.handle.net/10356/62222
الوسوم: إضافة وسم
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المؤسسة: Nanyang Technological University
اللغة: English
الوصف
الملخص:My Ph.D research mainly focuses on developing new reactions and synthetic methods via oxidative N-Heterocyclic Carbene catalysis. This thesis contains four major parts: Chapter 1 gives a brief introduction to history and present development of NHC catalysis, and shows the challenges in NHC catalysis need to be overcome. Chapter 2 discloses the first example of enolate equivalents generated from cleavage of C-C bond promoted by NHC catalysts. The innovative cyclolization of enolate equivalents with chalcones is investigated. Chapter 3 describes the oxidative NHC-catalyzed direct β-activation of simple saturated aldehydes. The oxidation of enolate intermediate in NHC catalysis is realized at the first time. Chapter 4 introduces the γ-activation of β-methyl cinnamaldehyde mediated by NHC. Vinyl enolate intermediate generated from deprotonation of α,β-unsaturated acyl azolium reacts with activated ketone to offer δ-lactone. Challenging enantioselective control is realized by Lewis acid/NHC co-operative catalysis.