Identifying the interaction between N-WASP, an actin nucleation factor and vinculin, a focal adhesion protein

• Main Author: Ganaesh
• Other Authors: Thirumaran s/o Thanabalu
• Format: Final Year Project
• Language: English
• Published: 2015
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/62233
• Institution: Nanyang Technological University

N-WASP belongs to the WASP family of proteins which regulate actin cytoskeleton remodeling via the activation of Arp2/3 complex. Arp2/3 complex interacts with vinculin, an intracellular focal adhesion protein. Knockdown of N-WASP have shown to have reduced the levels of vinculin patches which could...