Asymmetric synthesis of N-benzyl-5-methylhydroxy-piperidone and modular synthesis of C1-substituent tetrahydroisoquinolines (THIQ) and C2-symmetric bisisoquinolines (C2-BIQ) and their catalytic application in enantioselective Henry reaction

• Main Author: Khong, Duc Thinh
• Other Authors: Zaher Judeh
• Format: Theses and Dissertations
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/62256
• Institution: Nanyang Technological University

The core objective of this thesis is to develop effective strategies for the asymmetric synthesis of N-benzyl-5-methoxypiperidone, a common building block embedded in many biologically active compounds such as cytisine, vareniciline, paroxetine, tacamonine, and deplaincheine. Two main approaches wer...