Asymmetric synthesis of N-benzyl-5-methylhydroxy-piperidone and modular synthesis of C1-substituent tetrahydroisoquinolines (THIQ) and C2-symmetric bisisoquinolines (C2-BIQ) and their catalytic application in enantioselective Henry reaction
The core objective of this thesis is to develop effective strategies for the asymmetric synthesis of N-benzyl-5-methoxypiperidone, a common building block embedded in many biologically active compounds such as cytisine, vareniciline, paroxetine, tacamonine, and deplaincheine. Two main approaches wer...
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| 格式: | Theses and Dissertations |
| 語言: | English |
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2015
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| 在線閱讀: | https://hdl.handle.net/10356/62256 |
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