Computational analysis and prediction of specific genomic regions forming R-loop structure and chromosomal variations associated with cancer

• المؤلف الرئيسي: Wongsurawat, Thidathip
• مؤلفون آخرون: Vladimir Kuznetsov
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2015
• الموضوعات: DRNTU::Science::Biological sciences::Molecular biology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/62554
• المؤسسة: Nanyang Technological University

An R-loop is a structure formed co-transcriptionally between a nascent RNA and its template DNA strand, leaving the non-template DNA strand unpaired. I hypothesized that R-loops could form in many genes in mammalians, associate with transcription and genetic instability. I developed a quantitative m...