Computational analysis and prediction of specific genomic regions forming R-loop structure and chromosomal variations associated with cancer

An R-loop is a structure formed co-transcriptionally between a nascent RNA and its template DNA strand, leaving the non-template DNA strand unpaired. I hypothesized that R-loops could form in many genes in mammalians, associate with transcription and genetic instability. I developed a quantitative m...

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Bibliographic Details
Main Author: Wongsurawat, Thidathip
Other Authors: Vladimir Kuznetsov
Format: Theses and Dissertations
Language:English
Published: 2015
Subjects:
Online Access:https://hdl.handle.net/10356/62554
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Institution: Nanyang Technological University
Language: English
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