Structural basis for anticancer drug design : g-quadruplex-ligand complexes and aptamers

• Main Author: Chung, Wan Jun
• Other Authors: Phan Anh Tuan
• Format: Theses and Dissertations
• Language: English
• Published: 2015
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/63298
• Institution: Nanyang Technological University

Guanine-rich oligonucleotides have the propensity to fold into four-stranded helical structures known as G-quadruplex (G4). These structures are involved in cellular processes including replication, transcription and translation, with recent studies demonstrating their existence in cells. G4-forming...