Crystal structures of an HIV-1 integrase aptamer: formation of a water-mediated A•G•G•G•G pentad in an interlocked G-quadruplex

Crystal structures of an HIV-1 integrase aptamer: formation of a water-mediated A•G•G•G•G pentad in an interlocked G-quadruplex

93del is a 16-nucleotide G-quadruplex-forming aptamer which can inhibit the activity of the HIV-1 integrase enzyme at nanomolar concentration. Previous structural analyses of 93del using NMR spectroscopy have shown that the aptamer forms an interlocked G-quadruplex structure in K+ solution. Due to i...

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Bibliographic Details
Main Authors: Ngo, Khac Huy, Liew, Chong Wai, Lattmann, Simon, Winnerdy, Fernaldo Richtia, Phan, Anh Tuân
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Science::Chemistry
G-Quadruplexes
Interlocked
Online Access:https://hdl.handle.net/10356/158333
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/158333

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