Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter

• Main Authors: Chambers, Vicki S., Di Antonio, Marco, Sengar, Anjali, Balasubramanian, Shankar, Phan, Anh Tuân, Winnerdy, Fernaldo Richtia, Vandana, J. Jeya
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: G-quadruplex; PARP1 Promoter; Science::Chemistry
• Online Access: https://hdl.handle.net/10356/86025; http://hdl.handle.net/10220/49248
• Institution: Nanyang Technological University

Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in DNA repair processes. Inhibition of PARP1 in BRCA-mutated cancers has been observed to be clinically beneficial. Recent genome-mapping experiments have identified a non-canonical G-qu...