Structural basis for anticancer drug design : g-quadruplex-ligand complexes and aptamers
Guanine-rich oligonucleotides have the propensity to fold into four-stranded helical structures known as G-quadruplex (G4). These structures are involved in cellular processes including replication, transcription and translation, with recent studies demonstrating their existence in cells. G4-forming...
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| 格式: | Theses and Dissertations |
| 語言: | English |
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2015
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| 在線閱讀: | http://hdl.handle.net/10356/63298 |
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| 機構: | Nanyang Technological University |
| 語言: | English |