Eg5 and TPX2 in cohesion fatigue

The fidelity of chromosome segregation is ensured by organized cleavage of cohesin at the metaphase-to-anaphase transition. However, prolonged metaphase arrest by proteasomal inhibitor MG132 resulted in an asynchronous loss of sister chromatid cohesion, termed cohesion fatigue. Using immunofluoresce...

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Bibliographic Details
Main Author: Yeap, Szu Ling
Other Authors: Li Hoi Yeung
Format: Theses and Dissertations
Language:English
Published: 2015
Subjects:
Online Access:http://hdl.handle.net/10356/65060
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Institution: Nanyang Technological University
Language: English
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