Understanding Aβ dimer/inhibitor interactions from computer simulations

• Main Author: Zhang, Tong
• Other Authors: Mu Yuguang
• Format: Theses and Dissertations
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Biophysics; DRNTU::Science::Chemistry::Physical chemistry
• Online Access: http://hdl.handle.net/10356/65311
• Institution: Nanyang Technological University

Aggregation of the Amyloid β-protein (Aβ) peptide is one key feature in Alzheimer’s disease (AD). Growing evidence supports that Aβ oligomers are the major causative agents leading to neural cell death in Alzheimer’s disease. The polyphenol (-)-epigallocatechin gallate (EGCG) and 1,4-naphthoquinon-2...