Structural studies on hepatitis C virus (HCV) NS5A and its molecular interaction with CypA

• Main Author: Lee, Jia Jun
• Other Authors: Yoon Ho Sup
• Format: Theses and Dissertations
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Virology; DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/65353
• Institution: Nanyang Technological University

Hepatitis C virus infection is a worldwide issue and its NS5A protein interacts with host Cyclophilin A to play a crucial role in viral replication. To date, there is limited structural information for the intrinsically disordered NS5A protein. Here, low-resolution models of NS5A and NS5A-CypA from...