Fragment-based drug discovery and mechanistic studies of human thymidylate synthase

• 主要作者: Chen, Dan
• 其他作者: -
• 格式: Thesis-Doctor of Philosophy
• 語言: English
• 出版: Nanyang Technological University 2016
• 主題: DRNTU::Science::Biological sciences::Molecular biology
• 在線閱讀: https://hdl.handle.net/10356/65932
• 機構: Nanyang Technological University

Human thymidylate synthase (hTS) is the sole enzyme responsible for de novo biosynthesis of dTMP and is vital to cell proliferation and survival. Inhibition of hTS has been explored and found to be effective in cancer chemotherapy, while the efficacy is limited by drug resistance. Herein fragment sc...