CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Target engagement is a critical factor for therapeutic efficacy. Assessment of compound binding to native target proteins in live cells is therefore highly desirable in all stages of drug discovery. We report here the first compound library screen based on biophysical measurements of intracellular t...

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Bibliographic Details
Main Authors: Almqvist, Helena, Axelsson, Hanna, Jafari, Rozbeh, Dan, Chen, Mateus, André, Haraldsson, Martin, Larsson, Andreas, Molina, Daniel Martinez, Artursson, Per, Lundbäck, Thomas, Nordlund, Pär
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2018
Subjects:
Screening
DRNTU::Science::Biological sciences
Molecular Biophysics
Online Access:https://hdl.handle.net/10356/89820
http://hdl.handle.net/10220/47161
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/89820
http://hdl.handle.net/10220/47161

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