Characterizing the nucleosome site selectivity, adduct structures and impact on chromatin for a variety of metal-based anticancer compounds and structural studies of nucleosome-linker histone interactions

• Main Author: Adhireksan, Zenita
• Other Authors: Curtis Alexander Davey
• Format: Theses and Dissertations
• Language: English
• Published: 2016
• Subjects: DRNTU::Science::Biological sciences::Biochemistry; DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/66028
• Institution: Nanyang Technological University

The enormous length of DNA molecules is managed in the nucleus of eukaryotic cells by wrapping the double helix through histone protein association to form chromatin. The basic repeating unit of chromatin is the nucleosome. Due to this packaging, nucleosomal DNA and histones have different conformat...