Developing micro and nanostrategies for human cancer detection and therapy

In this thesis, micro and nano technologies were employed to create cancer therapies that can be customized for individuals by enhancing the therapeutic effects while simultaneously reducing the possible side-effects. Using a newly engineered Lab-On-a-Chip drug testing device, optimized drug formula...

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Main Author: Tng, Danny Jian Hang
Other Authors: Katrina Roslyn Keith
Format: Theses and Dissertations
Language:English
Published: 2016
Subjects:
Online Access:http://hdl.handle.net/10356/66312
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-663122023-07-04T16:09:34Z Developing micro and nanostrategies for human cancer detection and therapy Tng, Danny Jian Hang Katrina Roslyn Keith School of Electrical and Electronic Engineering Yong Ken-Tye DRNTU::Engineering In this thesis, micro and nano technologies were employed to create cancer therapies that can be customized for individuals by enhancing the therapeutic effects while simultaneously reducing the possible side-effects. Using a newly engineered Lab-On-a-Chip drug testing device, optimized drug formulations for killing the cancer in vitro were determined. These drug formulations were then loaded into multifunctional hybrid-polymeric nanoparticles for enhancing tumor uptake and improving providing targeted delivery in vivo. In addition, these nanoparticles were equipped with multimodal imaging capabilities (e.g. fluorescence and magnetic resonance imaging), allowing real-time monitoring of the biodistribution and efficacy of the nanodrugs in vivo. Lastly, to further improve the delivery of the nanodrugs locally, biocompatible microelectromechanical system devices were fabricated and implanted into small animals for evaluation of the pharmacokinetics of programmed drug delivery. The use of these approaches allows treatment to be tailored for the individual, thereby enhancing the therapeutic outcomes. Doctor of Philosophy (EEE) 2016-03-24T03:53:44Z 2016-03-24T03:53:44Z 2016 Thesis Tng, D. J. H. (2016). Developing micro and nanostrategies for human cancer detection and therapy. Doctoral thesis, Nanyang Technological University, Singapore. http://hdl.handle.net/10356/66312 en 169 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering
spellingShingle DRNTU::Engineering
Tng, Danny Jian Hang
Developing micro and nanostrategies for human cancer detection and therapy
description In this thesis, micro and nano technologies were employed to create cancer therapies that can be customized for individuals by enhancing the therapeutic effects while simultaneously reducing the possible side-effects. Using a newly engineered Lab-On-a-Chip drug testing device, optimized drug formulations for killing the cancer in vitro were determined. These drug formulations were then loaded into multifunctional hybrid-polymeric nanoparticles for enhancing tumor uptake and improving providing targeted delivery in vivo. In addition, these nanoparticles were equipped with multimodal imaging capabilities (e.g. fluorescence and magnetic resonance imaging), allowing real-time monitoring of the biodistribution and efficacy of the nanodrugs in vivo. Lastly, to further improve the delivery of the nanodrugs locally, biocompatible microelectromechanical system devices were fabricated and implanted into small animals for evaluation of the pharmacokinetics of programmed drug delivery. The use of these approaches allows treatment to be tailored for the individual, thereby enhancing the therapeutic outcomes.
author2 Katrina Roslyn Keith
author_facet Katrina Roslyn Keith
Tng, Danny Jian Hang
format Theses and Dissertations
author Tng, Danny Jian Hang
author_sort Tng, Danny Jian Hang
title Developing micro and nanostrategies for human cancer detection and therapy
title_short Developing micro and nanostrategies for human cancer detection and therapy
title_full Developing micro and nanostrategies for human cancer detection and therapy
title_fullStr Developing micro and nanostrategies for human cancer detection and therapy
title_full_unstemmed Developing micro and nanostrategies for human cancer detection and therapy
title_sort developing micro and nanostrategies for human cancer detection and therapy
publishDate 2016
url http://hdl.handle.net/10356/66312
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