Development of UV-crosslinkable hybrid 3D hydrogels
The project aims to develop UV-crosslinkable hybrid 3D hydrogel with tailorable physical and chemical properties for future cell culture studies in the field of tissue engineering. A hydrogel system were designed by incorporating FN910 protein into a PEG precursor. The protein were expressed and pur...
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sg-ntu-dr.10356-664772023-03-04T15:36:42Z Development of UV-crosslinkable hybrid 3D hydrogels Wicaksono, Gautama Fong Wen Mei, Eileen School of Materials Science and Engineering DRNTU::Engineering The project aims to develop UV-crosslinkable hybrid 3D hydrogel with tailorable physical and chemical properties for future cell culture studies in the field of tissue engineering. A hydrogel system were designed by incorporating FN910 protein into a PEG precursor. The protein were expressed and purified successfully, and were subsequently crosslinked into the PEG via UV-initiated thiol-ene click chemistry. The resulting hydrogel were characterized by varying the ratio of the protein and the PEG. The hydrogel system was shown to be tunable into a wide range of stiffness, demonstrating their promise in imitating natural body tissues, while being independent from biochemical cues. Bachelor of Engineering (Materials Engineering) 2016-04-12T08:46:26Z 2016-04-12T08:46:26Z 2016 Final Year Project (FYP) http://hdl.handle.net/10356/66477 en Nanyang Technological University 29 p. application/pdf |
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DRNTU::Engineering Wicaksono, Gautama Development of UV-crosslinkable hybrid 3D hydrogels |
| description |
The project aims to develop UV-crosslinkable hybrid 3D hydrogel with tailorable physical and chemical properties for future cell culture studies in the field of tissue engineering. A hydrogel system were designed by incorporating FN910 protein into a PEG precursor. The protein were expressed and purified successfully, and were subsequently crosslinked into the PEG via UV-initiated thiol-ene click chemistry. The resulting hydrogel were characterized by varying the ratio of the protein and the PEG. The hydrogel system was shown to be tunable into a wide range of stiffness, demonstrating their promise in imitating natural body tissues, while being independent from biochemical cues. |
| author2 |
Fong Wen Mei, Eileen |
| author_facet |
Fong Wen Mei, Eileen Wicaksono, Gautama |
| format |
Final Year Project |
| author |
Wicaksono, Gautama |
| author_sort |
Wicaksono, Gautama |
| title |
Development of UV-crosslinkable hybrid 3D hydrogels |
| title_short |
Development of UV-crosslinkable hybrid 3D hydrogels |
| title_full |
Development of UV-crosslinkable hybrid 3D hydrogels |
| title_fullStr |
Development of UV-crosslinkable hybrid 3D hydrogels |
| title_full_unstemmed |
Development of UV-crosslinkable hybrid 3D hydrogels |
| title_sort |
development of uv-crosslinkable hybrid 3d hydrogels |
| publishDate |
2016 |
| url |
http://hdl.handle.net/10356/66477 |
| _version_ |
1759854050078097408 |