Chromatin changes induced by nuclear lamina in embryonic stem cell

• Main Author: Siah, Chia Keng
• Other Authors: Colin Stewart
• Format: Final Year Project
• Language: English
• Published: 2016
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/67170
• Institution: Nanyang Technological University

The Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by a mutation in the LMNA gene, which leads to the premature ageing of affected children. This mutation triggers the production of progerin, a truncated form of the lamin A protein. Progerin has recently been shown to...