Development of an in-vitro rheumatoid arthritis (RA) model and its application in anti-rheumatic drug testing

• Main Author: Tan, Kian Siong
• Other Authors: Wang Dongan
• Format: Final Year Project
• Language: English
• Published: 2016
• Subjects: DRNTU::Engineering::Bioengineering
• Online Access: http://hdl.handle.net/10356/67388
• Institution: Nanyang Technological University

This study describe the evaluation of Celecoxib on a newly established in vitro three-dimensional Rheumatoid Arthritis (RA) model, by co-culturing LhCG with effector cells of RA namely, RA Synovial Fibroblast, Macrophage and Chondrocytes, this model was able to mimic the cartilage degradation condit...