Computer modelling on human telomeric dna g-quadruplexes, from stability, folding dynamics to ligand binding

G-quadruplex is a non-canonical yet crucial secondary structure of nucleic acids, which has proven its importance in cell aging, anti-cancer therapies, gene expression and genome stability. In this PhD thesis, we studied the five established structural models of human telomeric DNA G-quadruplexes on...

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Bibliographic Details
Main Author: Luo, Di
Other Authors: Mu Yuguang
Format: Theses and Dissertations
Language:English
Published: 2016
Subjects:
Online Access:http://hdl.handle.net/10356/68827
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Institution: Nanyang Technological University
Language: English