Structural and functional studies of leukemia-associated mutations in human cytosolic 5'-nucleotidase II

• Main Author: Lim, Pei Yiing
• Other Authors: Pär Nordlund
• Format: Theses and Dissertations
• Language: English
• Published: 2016
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/69099
• Institution: Nanyang Technological University

NT5C2 relapse-associated mutations, K359Q and R367Q, are correlated with large gains in their enzymatic profiles. Crystal structures obtained in this study provide insights to the allosteric regulation mechanism of the enzyme by the disorder-to-order transition of a regulatory helix, which forms par...