Investigation on the conformational conversion of human prion protein by molecular dynamics simulation
Conformational conversion of normal α-rich cellular prion protein PrP^C to its oligomeric β-rich isoform PrP^Sc can lead to fatal prion diseases. Despite numerous studies, the underlying mechanism for the β-enrichment during the conversion still remains elusive. In this molecular dynamics (MD) study...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/10356/70177 |
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| Institution: | Nanyang Technological University |
| Language: | English |