Investigation on the conformational conversion of human prion protein by molecular dynamics simulation

• Main Author: Yang, Hong
• Other Authors: Li Tianhu
• Format: Theses and Dissertations
• Language: English
• Published: 2017
• Subjects: DRNTU::Science::Chemistry
• Online Access: http://hdl.handle.net/10356/70177
• Institution: Nanyang Technological University

Conformational conversion of normal α-rich cellular prion protein PrP^C to its oligomeric β-rich isoform PrP^Sc can lead to fatal prion diseases. Despite numerous studies, the underlying mechanism for the β-enrichment during the conversion still remains elusive. In this molecular dynamics (MD) study...