Magnetically actuable delivery vehicles
Stimuli-responsive amphiphilic superstructures comprise some of the most successful drug delivery systems in clinical use. Vesicular assemblies in particular, have long been recognized as excellent carrier systems for diagnostic and therapeutic agents due to their potential to encapsulate, tra...
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| Main Author: | |
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
| Published: |
Nanyang Technological University
2017
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/70636 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Stimuli-responsive amphiphilic superstructures comprise some of the most
successful drug delivery systems in clinical use. Vesicular assemblies in particular,
have long been recognized as excellent carrier systems for diagnostic and
therapeutic agents due to their potential to encapsulate, transport and release
various cargo upon local changes; the latter in response to the microenvironment.
Structural incorporation of biocompatible, functional nanomaterials such as
superparamagnetic iron oxide nanoparticles can be employed to design universal
delivery systems, whose release profiles can be controlled externally by application
of a magnetic field. The aim of this work is to establish a theranostic platform by
incorporating hydrophobic SPIONs of controlled size and interfacial chemistry into
stimuli-responsive amphiphilic superstructures and to demonstrate externally
triggered release of a model compound via magnetic actuation. The synthesis of
monodisperse nanocrystals and complete exchange of the native hydrophobic
dispersant shell for irreversibly grafted nitrocatechol-derived anchors at maximal
ligand density is exemplified and shown crucial for controlled capsule assembly. A
method for efficient encapsulation of SPION into amphiphile membranes is outlined
that allows for direct and quantitative co-self-assembly of bilayer forming amphiphiles
with hydrophobic nanoparticles into controlled magnetosomes. The novel method
allowed for controlling the vesicle size, lamellarity and the nanoparticle concentration
in the membrane with retained vesicle stability. Various capsule systems comprising
polymeric superamphiphiles and mixed lipid/superamphiphile blends were
investigated and their magnetothermal release efficiencies using alternating magnetic
field irradiation to cause local hyperthermia were compared. Mixed membrane
capsules were found to combine efficient magnetothermal actuation with the high
stability of purely polymeric membrane systems. |
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