Biology of murine CD84 in the context of autoimmunity
Systemic lupus erythematosus (SLE) is characterized by the production of autoantibodies (ANAs), these form self-reactive immune complexes with self-antigens which results in tissue inflammation. The SLAM family (SLAMF) receptors are regulators of the innate and adaptive immune response. In mice,...
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| Other Authors: | |
| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/71172 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Systemic lupus erythematosus (SLE) is characterized by the production of
autoantibodies (ANAs), these form self-reactive immune complexes with self-antigens which
results in tissue inflammation. The SLAM family (SLAMF) receptors are regulators of the
innate and adaptive immune response. In mice, SLAMF are located within the sle1 lupussusceptibility
locus. When present on a B6 background, sle1 drives B and T cell hyperreactivity
and ANAs production. |
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