The effects of H3.3 mutation on ES stem cell self renewal, pluripotency and differentiation

Recent studies have shed light on mutations of H3.3 N-terminal tail and the role it plays in neoplastic diseases such as paediatric diffuse intrinsic pontine glioma (DIPG) and chondroblastomas. However, little is known on how these H3.3 single amino acid substitutions can affect embryonic stem cell...

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Bibliographic Details
Main Author: Sim, Wei Xiong
Other Authors: Lim Chin Yan
Format: Final Year Project
Language:English
Published: 2017
Subjects:
Online Access:http://hdl.handle.net/10356/72050
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Institution: Nanyang Technological University
Language: English