The effects of H3.3 mutation on ES stem cell self renewal, pluripotency and differentiation

• Main Author: Sim, Wei Xiong
• Other Authors: Lim Chin Yan
• Format: Final Year Project
• Language: English
• Published: 2017
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/72050
• Institution: Nanyang Technological University

Recent studies have shed light on mutations of H3.3 N-terminal tail and the role it plays in neoplastic diseases such as paediatric diffuse intrinsic pontine glioma (DIPG) and chondroblastomas. However, little is known on how these H3.3 single amino acid substitutions can affect embryonic stem cell...