Nanoparticle incorporated polymer brush films for sensing interfaces

• Main Author: Ferhan Oktobriadi Putra Abdul Rahim
• Other Authors: Kim Donghwan, Richie
• Format: Theses and Dissertations
• Language: English
• Published: 2017
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/72401
• Institution: Nanyang Technological University

The use of polymer brushes has been attracting attention in recent years due to its ability to reduce non-specific adsorption of proteins on a surface. At the same time, noble metal nanoparticles has been widely exploited for chemical and biomolecular sensing applications, particularly via localized surface plasmon resonance and surface enhanced raman spectroscopy. While many conventional plasmonic, nanoparticle solution-based detection methods offer direct observation with high sensitivity and selectivity, they have several limitations. For example, it is difficult to discern color hue or intensity changes in colored samples or complex mixtures such as blood and serum. Nanoparticle in solution are also prone to aggregation over time, reducing shelf life.