Identification of SRSF1 binding site regulating BIM splicing and its role in leukemia drug response

• Main Author: Tan, Cheryl Weiqi
• Other Authors: Francesco Paolo Cavallaro
• Format: Final Year Project
• Language: English
• Published: 2017
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/72706
• Institution: Nanyang Technological University

BCL-2-Interacting Mediator of Cell Death (BIM) is a pro-apoptotic BH3-only protein that plays an important role in regulating apoptosis. Hence, its deregulation is often observed in cancer as well as drug resistance. Alternative splicing give rise to different BIM transcripts, which translates into...