Multifunctional nanomaterials for cancer theranostics applications
Limited success in early diagnosis of pancreatic cancer, combined with lack of effective treatment options have resulted in low survival rate for pancreatic cancer patients. Current therapy option such as chemotherapy poses toxic side effects and low therapeutic efficacy. In our work, we aim to s...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/10356/72721 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Limited success in early diagnosis of pancreatic cancer, combined with lack of effective
treatment options have resulted in low survival rate for pancreatic cancer patients. Current
therapy option such as chemotherapy poses toxic side effects and low therapeutic efficacy. In
our work, we aim to solve this challenge by utilizing multifunctional nanomaterials for cancer
theranostics applications. Organic biodegradable nanomaterials such as cationic polylactides
were applied for RNA interference gene therapy for pancreatic cancer and their efficiency and
therapeutic efficacy were evaluated. We investigated applications of inorganic materials with
interesting properties, such as 1-dimensional carbon nanotubes, 0-dimensional graphene
quantum dots, and 2-dimensional transition metal dichalcogenides. Functionalization of these
nanomaterials was carried out to improve their biocompatibility and allow conjugation with
therapeutic materials to act as efficient transfection agent for gene therapy in pancreatic cancer
cells. Intrinsic properties of these nanomaterials are also advantageous for application such as
imaging of cancer cells. In these works, we investigated and demonstrated the application of
nanomaterials and their potential for improvements in cancer theranostics, especially in gene
therapy and imaging of pancreatic cancer. |
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