Multifunctional nanomaterials for cancer theranostics applications

Limited success in early diagnosis of pancreatic cancer, combined with lack of effective treatment options have resulted in low survival rate for pancreatic cancer patients. Current therapy option such as chemotherapy poses toxic side effects and low therapeutic efficacy. In our work, we aim to s...

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Main Author: Anderson, Tommy
Other Authors: Yong, Ken Tye
Format: Theses and Dissertations
Language:English
Published: 2017
Subjects:
Online Access:http://hdl.handle.net/10356/72721
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-727212023-07-04T17:26:10Z Multifunctional nanomaterials for cancer theranostics applications Anderson, Tommy Yong, Ken Tye School of Electrical and Electronic Engineering DRNTU::Engineering::Nanotechnology Limited success in early diagnosis of pancreatic cancer, combined with lack of effective treatment options have resulted in low survival rate for pancreatic cancer patients. Current therapy option such as chemotherapy poses toxic side effects and low therapeutic efficacy. In our work, we aim to solve this challenge by utilizing multifunctional nanomaterials for cancer theranostics applications. Organic biodegradable nanomaterials such as cationic polylactides were applied for RNA interference gene therapy for pancreatic cancer and their efficiency and therapeutic efficacy were evaluated. We investigated applications of inorganic materials with interesting properties, such as 1-dimensional carbon nanotubes, 0-dimensional graphene quantum dots, and 2-dimensional transition metal dichalcogenides. Functionalization of these nanomaterials was carried out to improve their biocompatibility and allow conjugation with therapeutic materials to act as efficient transfection agent for gene therapy in pancreatic cancer cells. Intrinsic properties of these nanomaterials are also advantageous for application such as imaging of cancer cells. In these works, we investigated and demonstrated the application of nanomaterials and their potential for improvements in cancer theranostics, especially in gene therapy and imaging of pancreatic cancer. Doctor of Philosophy (EEE) 2017-10-26T09:35:18Z 2017-10-26T09:35:18Z 2017 Thesis Anderson, T. (2017). Multifunctional nanomaterials for cancer theranostics applications. Doctoral thesis, Nanyang Technological University, Singapore. http://hdl.handle.net/10356/72721 10.32657/10356/72721 en 150 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Nanotechnology
spellingShingle DRNTU::Engineering::Nanotechnology
Anderson, Tommy
Multifunctional nanomaterials for cancer theranostics applications
description Limited success in early diagnosis of pancreatic cancer, combined with lack of effective treatment options have resulted in low survival rate for pancreatic cancer patients. Current therapy option such as chemotherapy poses toxic side effects and low therapeutic efficacy. In our work, we aim to solve this challenge by utilizing multifunctional nanomaterials for cancer theranostics applications. Organic biodegradable nanomaterials such as cationic polylactides were applied for RNA interference gene therapy for pancreatic cancer and their efficiency and therapeutic efficacy were evaluated. We investigated applications of inorganic materials with interesting properties, such as 1-dimensional carbon nanotubes, 0-dimensional graphene quantum dots, and 2-dimensional transition metal dichalcogenides. Functionalization of these nanomaterials was carried out to improve their biocompatibility and allow conjugation with therapeutic materials to act as efficient transfection agent for gene therapy in pancreatic cancer cells. Intrinsic properties of these nanomaterials are also advantageous for application such as imaging of cancer cells. In these works, we investigated and demonstrated the application of nanomaterials and their potential for improvements in cancer theranostics, especially in gene therapy and imaging of pancreatic cancer.
author2 Yong, Ken Tye
author_facet Yong, Ken Tye
Anderson, Tommy
format Theses and Dissertations
author Anderson, Tommy
author_sort Anderson, Tommy
title Multifunctional nanomaterials for cancer theranostics applications
title_short Multifunctional nanomaterials for cancer theranostics applications
title_full Multifunctional nanomaterials for cancer theranostics applications
title_fullStr Multifunctional nanomaterials for cancer theranostics applications
title_full_unstemmed Multifunctional nanomaterials for cancer theranostics applications
title_sort multifunctional nanomaterials for cancer theranostics applications
publishDate 2017
url http://hdl.handle.net/10356/72721
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