Structural studies on proteins involved in human telomere maintenance

• Main Author: Ufuk Borucu
• Other Authors: Daniela Rhodes
• Format: Theses and Dissertations
• Language: English
• Published: 2017
• Subjects: DRNTU::Science::Chemistry::Crystallography::Electron microscopy; DRNTU::Science::Chemistry::Crystallography::X-ray crystallography; DRNTU::Science::Chemistry::Analytical chemistry::Proteins
• Online Access: http://hdl.handle.net/10356/72778
• Institution: Nanyang Technological University

In order to sustain genomic stability and cellular viability, the ends of linear eukaryotic chromosomes are capped and protected by telomeres. The mechanism by which the length of telomeric DNA is maintained involves a specialized reverse transcriptase, called telomerase. This thesis focuses on t...