Investigating key function-altering mutations in asparaginyl endopeptidase butelase 2

• Main Author: Ng, Jia Hao
• Other Authors: James P. Tam
• Format: Final Year Project
• Language: English
• Published: 2018
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/74165
• Institution: Nanyang Technological University

Butelase 2 is a natural protease derived from Clitoria ternatea, the same plant where the fastest known AEP ligase butelase 1 was discovered. The fundamental function of AEP ligases is to macrocyclize cyclotides to achieve ultra-stable forms and new biological functions beneficial to drug discovery...