Investigating insight in mice through behaviour and neural connectivity analysis

Insight is a rapid change in the brain that leads to a sudden solution, and is critical for creativity and innovation. Several brain regions, such as the prefrontal cortex, cingulate cortex and hippocampus, are involved in insight. However, the exact mechanisms underlying insight remain unclear. We...

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Main Author: Yue, Wan Lin
Other Authors: Hiroshi Makino
Format: Final Year Project
Language:English
Published: 2018
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Online Access:http://hdl.handle.net/10356/74186
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-741862023-02-28T18:01:42Z Investigating insight in mice through behaviour and neural connectivity analysis Yue, Wan Lin Hiroshi Makino School of Biological Sciences DRNTU::Science::Biological sciences DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology Insight is a rapid change in the brain that leads to a sudden solution, and is critical for creativity and innovation. Several brain regions, such as the prefrontal cortex, cingulate cortex and hippocampus, are involved in insight. However, the exact mechanisms underlying insight remain unclear. We aim to investigate if insight occurs during an auditory two-alternative forced choice (2AFC) task, in which mice are required to respond differently to two tones, and thus determine if this task is suitable for studying insight. We also aim to design neuronal tracers to identify changes in neuronal connections accompanying insight. We optimised the 2AFC task and used learning curves to investigate if insight learning has taken place, and modelled the behaviour of the mice. Learning in the 2AFC task appeared to be gradual instead of sudden. Further modification of the task could verify if other factors are masking insight learning, or if insight is truly not occurring. In addition, we proposed several methods using modified self-inactivating rabies virus (SiR) to probe changes in neuronal connections accompanying insight. In the future, modified SiR can be produced using these designs and combined with a learning task involving insight to track underlying changes in neuronal connections. Bachelor of Science in Biological Sciences 2018-05-07T00:57:00Z 2018-05-07T00:57:00Z 2018 Final Year Project (FYP) http://hdl.handle.net/10356/74186 en Nanyang Technological University 38 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences
DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
spellingShingle DRNTU::Science::Biological sciences
DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
Yue, Wan Lin
Investigating insight in mice through behaviour and neural connectivity analysis
description Insight is a rapid change in the brain that leads to a sudden solution, and is critical for creativity and innovation. Several brain regions, such as the prefrontal cortex, cingulate cortex and hippocampus, are involved in insight. However, the exact mechanisms underlying insight remain unclear. We aim to investigate if insight occurs during an auditory two-alternative forced choice (2AFC) task, in which mice are required to respond differently to two tones, and thus determine if this task is suitable for studying insight. We also aim to design neuronal tracers to identify changes in neuronal connections accompanying insight. We optimised the 2AFC task and used learning curves to investigate if insight learning has taken place, and modelled the behaviour of the mice. Learning in the 2AFC task appeared to be gradual instead of sudden. Further modification of the task could verify if other factors are masking insight learning, or if insight is truly not occurring. In addition, we proposed several methods using modified self-inactivating rabies virus (SiR) to probe changes in neuronal connections accompanying insight. In the future, modified SiR can be produced using these designs and combined with a learning task involving insight to track underlying changes in neuronal connections.
author2 Hiroshi Makino
author_facet Hiroshi Makino
Yue, Wan Lin
format Final Year Project
author Yue, Wan Lin
author_sort Yue, Wan Lin
title Investigating insight in mice through behaviour and neural connectivity analysis
title_short Investigating insight in mice through behaviour and neural connectivity analysis
title_full Investigating insight in mice through behaviour and neural connectivity analysis
title_fullStr Investigating insight in mice through behaviour and neural connectivity analysis
title_full_unstemmed Investigating insight in mice through behaviour and neural connectivity analysis
title_sort investigating insight in mice through behaviour and neural connectivity analysis
publishDate 2018
url http://hdl.handle.net/10356/74186
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