Investigating insight in mice through behaviour and neural connectivity analysis
Insight is a rapid change in the brain that leads to a sudden solution, and is critical for creativity and innovation. Several brain regions, such as the prefrontal cortex, cingulate cortex and hippocampus, are involved in insight. However, the exact mechanisms underlying insight remain unclear. We...
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sg-ntu-dr.10356-741862023-02-28T18:01:42Z Investigating insight in mice through behaviour and neural connectivity analysis Yue, Wan Lin Hiroshi Makino School of Biological Sciences DRNTU::Science::Biological sciences DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology Insight is a rapid change in the brain that leads to a sudden solution, and is critical for creativity and innovation. Several brain regions, such as the prefrontal cortex, cingulate cortex and hippocampus, are involved in insight. However, the exact mechanisms underlying insight remain unclear. We aim to investigate if insight occurs during an auditory two-alternative forced choice (2AFC) task, in which mice are required to respond differently to two tones, and thus determine if this task is suitable for studying insight. We also aim to design neuronal tracers to identify changes in neuronal connections accompanying insight. We optimised the 2AFC task and used learning curves to investigate if insight learning has taken place, and modelled the behaviour of the mice. Learning in the 2AFC task appeared to be gradual instead of sudden. Further modification of the task could verify if other factors are masking insight learning, or if insight is truly not occurring. In addition, we proposed several methods using modified self-inactivating rabies virus (SiR) to probe changes in neuronal connections accompanying insight. In the future, modified SiR can be produced using these designs and combined with a learning task involving insight to track underlying changes in neuronal connections. Bachelor of Science in Biological Sciences 2018-05-07T00:57:00Z 2018-05-07T00:57:00Z 2018 Final Year Project (FYP) http://hdl.handle.net/10356/74186 en Nanyang Technological University 38 p. application/pdf |
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DRNTU::Science::Biological sciences DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology Yue, Wan Lin Investigating insight in mice through behaviour and neural connectivity analysis |
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Insight is a rapid change in the brain that leads to a sudden solution, and is critical for creativity and innovation. Several brain regions, such as the prefrontal cortex, cingulate cortex and hippocampus, are involved in insight. However, the exact mechanisms underlying insight remain unclear. We aim to investigate if insight occurs during an auditory two-alternative forced choice (2AFC) task, in which mice are required to respond differently to two tones, and thus determine if this task is suitable for studying insight. We also aim to design neuronal tracers to identify changes in neuronal connections accompanying insight. We optimised the 2AFC task and used learning curves to investigate if insight learning has taken place, and modelled the behaviour of the mice. Learning in the 2AFC task appeared to be gradual instead of sudden. Further modification of the task could verify if other factors are masking insight learning, or if insight is truly not occurring. In addition, we proposed several methods using modified self-inactivating rabies virus (SiR) to probe changes in neuronal connections accompanying insight. In the future, modified SiR can be produced using these designs and combined with a learning task involving insight to track underlying changes in neuronal connections. |
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Hiroshi Makino |
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Hiroshi Makino Yue, Wan Lin |
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Final Year Project |
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Yue, Wan Lin |
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Yue, Wan Lin |
title |
Investigating insight in mice through behaviour and neural connectivity analysis |
title_short |
Investigating insight in mice through behaviour and neural connectivity analysis |
title_full |
Investigating insight in mice through behaviour and neural connectivity analysis |
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Investigating insight in mice through behaviour and neural connectivity analysis |
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Investigating insight in mice through behaviour and neural connectivity analysis |
title_sort |
investigating insight in mice through behaviour and neural connectivity analysis |
publishDate |
2018 |
url |
http://hdl.handle.net/10356/74186 |
_version_ |
1759855673058787328 |