Study of mechanical strength and release profile of microneedles made of polymer nanocomposites
Microneedles are individual needles or arrays of needles in micro-scale widely used in transdermal drug delivery. They achieve painless administration with delivery of low but sufficient dose of therapeutic agents. Dissolving microneedles, made from biodegradable materials, are able to control dr...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/75256 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Microneedles are individual needles or arrays of needles in micro-scale widely used
in transdermal drug delivery. They achieve painless administration with delivery of
low but sufficient dose of therapeutic agents. Dissolving microneedles, made from
biodegradable materials, are able to control drug release by altering their
compositions and fabrication processes. This article proposed with new methods to
improve the mechanical strength and the drug duration of the biodegradable
microneedles based on MeHA. These new methods showed dramatically
improvement in mechanical strength for penetration of flat skin model and irregular
surface model, which are very promising for drug delivery for skin diseases in further
study. |
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