Study of mechanical strength and release profile of microneedles made of polymer nanocomposites
Microneedles are individual needles or arrays of needles in micro-scale widely used in transdermal drug delivery. They achieve painless administration with delivery of low but sufficient dose of therapeutic agents. Dissolving microneedles, made from biodegradable materials, are able to control dr...
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sg-ntu-dr.10356-752562023-03-03T16:07:59Z Study of mechanical strength and release profile of microneedles made of polymer nanocomposites Zhou, Meixin Chen Peng School of Chemical and Biomedical Engineering DRNTU::Engineering::Bioengineering Microneedles are individual needles or arrays of needles in micro-scale widely used in transdermal drug delivery. They achieve painless administration with delivery of low but sufficient dose of therapeutic agents. Dissolving microneedles, made from biodegradable materials, are able to control drug release by altering their compositions and fabrication processes. This article proposed with new methods to improve the mechanical strength and the drug duration of the biodegradable microneedles based on MeHA. These new methods showed dramatically improvement in mechanical strength for penetration of flat skin model and irregular surface model, which are very promising for drug delivery for skin diseases in further study. Master of Science (Biomedical Engineering) 2018-05-30T06:34:17Z 2018-05-30T06:34:17Z 2018 Thesis http://hdl.handle.net/10356/75256 en 39 p. application/pdf |
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DRNTU::Engineering::Bioengineering |
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DRNTU::Engineering::Bioengineering Zhou, Meixin Study of mechanical strength and release profile of microneedles made of polymer nanocomposites |
| description |
Microneedles are individual needles or arrays of needles in micro-scale widely used
in transdermal drug delivery. They achieve painless administration with delivery of
low but sufficient dose of therapeutic agents. Dissolving microneedles, made from
biodegradable materials, are able to control drug release by altering their
compositions and fabrication processes. This article proposed with new methods to
improve the mechanical strength and the drug duration of the biodegradable
microneedles based on MeHA. These new methods showed dramatically
improvement in mechanical strength for penetration of flat skin model and irregular
surface model, which are very promising for drug delivery for skin diseases in further
study. |
| author2 |
Chen Peng |
| author_facet |
Chen Peng Zhou, Meixin |
| format |
Theses and Dissertations |
| author |
Zhou, Meixin |
| author_sort |
Zhou, Meixin |
| title |
Study of mechanical strength and release profile of microneedles made of polymer nanocomposites |
| title_short |
Study of mechanical strength and release profile of microneedles made of polymer nanocomposites |
| title_full |
Study of mechanical strength and release profile of microneedles made of polymer nanocomposites |
| title_fullStr |
Study of mechanical strength and release profile of microneedles made of polymer nanocomposites |
| title_full_unstemmed |
Study of mechanical strength and release profile of microneedles made of polymer nanocomposites |
| title_sort |
study of mechanical strength and release profile of microneedles made of polymer nanocomposites |
| publishDate |
2018 |
| url |
http://hdl.handle.net/10356/75256 |
| _version_ |
1759858184618508288 |