Modelling Mitchell-Riley Syndrome in vitro using iPS cells derived from RFX6 mutant patient

The forkhead transcription factor Regulatory Factor X, 6 (RFX6) is essential for the development of the mammalian pancreas. In humans, RFX6 mutations are responsible for Mitchell-Riley Syndrome (MRS), which is characterized by neonatal diabetes with pancreatic hypoplasia. Similarly, Rfx6 mutant mice...

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Bibliographic Details
Main Author: Alpagu, Yunus
Other Authors: Ray Dunn
Format: Theses and Dissertations
Language:English
Published: 2018
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Online Access:http://hdl.handle.net/10356/75844
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Institution: Nanyang Technological University
Language: English