Targeting adenosine-2 B receptor : a potential metabolic immune checkpoint

Adenosine is an anti-inflammatory and immunosuppressive metabolite that binds to the adenosine receptors (AR) - A1R, A2AR, A2BR and A3R. Adenosine immunosuppression is mediated via A2Rs, with A2BR only activated by high adenosine concentration such as within solid tumor microenvironments (TME). A...

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Bibliographic Details
Main Author: Tay, Hui Min
Other Authors: Andreas Lundqvist
Format: Final Year Project
Language:English
Published: 2019
Subjects:
Online Access:http://hdl.handle.net/10356/77108
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Institution: Nanyang Technological University
Language: English