Understanding the impact of DNMT3A Knockout on K562 cell sensitivity towards epigenetic drug treatments

DNMT3A mutation has been seen as a marker of acute myeloid leukaemia. DNMT3A mutation can cause genome methylation changes and the reliance on other epigenetic modifiers including other methyltransferases for maintaining regular gene expression for survival. The loss of the remaining epigenetic modi...

Full description

Saved in:
Bibliographic Details
Main Author: Mah, Lian-Khye
Other Authors: Melissa Jane Fullwood
Format: Final Year Project
Language:English
Published: 2019
Subjects:
Online Access:http://hdl.handle.net/10356/78545
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English