Understanding the impact of DNMT3A Knockout on K562 cell sensitivity towards epigenetic drug treatments

• Main Author: Mah, Lian-Khye
• Other Authors: Melissa Jane Fullwood
• Format: Final Year Project
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/78545
• Institution: Nanyang Technological University

DNMT3A mutation has been seen as a marker of acute myeloid leukaemia. DNMT3A mutation can cause genome methylation changes and the reliance on other epigenetic modifiers including other methyltransferases for maintaining regular gene expression for survival. The loss of the remaining epigenetic modi...