A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction

• Main Authors: Martin, Fernando L., Huang, Ying Ying, Venkatraman, Subbu Subramanian, Burnett, John C., Chen, Horng H., Lim, Soo Ghim, Jeson Sangaralingham, S., Ameenuddin, Syed, Ng, Xu Wen
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/79313; http://hdl.handle.net/10220/38543
• Institution: Nanyang Technological University

CD-NP (Cenderitide) is the only chimeric natriuretic peptide that acts on both the A and B natriuretic peptide receptors (NPR). This differential mechanism of action reduces the arterial vasodilating properties, while retaining the cardiac unloading and aldosterone inhibiting actions of the NPR-A receptor in addition to the direct anti-remodeling actions of the NPR-B receptor. Our objective is to determine the effects of 3 weeks of sustained delivery of CD-NP via a single subcutaneous (SQ) injection of a fully biodegradable in-situ polymer precipitation delivery system (Gel system) in a model of experimental myocardial infarction (MI).